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浙江省医学科学院——“世界卫生组织蠕虫病研究合作中心”工作报告
一、“中心”概况
浙江省医学科学院寄生虫病研究所（简称研究所）于1984年经世界卫生组织西太地区办事局（简称WP/WHO）及我国卫生部批准为世界卫生组织蠕虫病研究合作中心（简称中心），其主要任务为促进和开展以土源性线虫病和血吸虫病为主的蠕虫病防治科研工作。
“中心”成立后受到各级领导的重视和支持，原WHO西太地区事务局局长中岛宏博士、原卫生部陈敏章部长都曾亲临视察和指导，著名寄生虫学家毛守白教授和赵慰先教授曾担任“中心”的顾问，并对“中心”工作进行了卓有成效的指导。原研究所所长、原卫生部寄生虫病专家咨询委员会主任委员宋昌存教授1984-2002年担任“中心”的主任；现研究所所长、卫生部血吸虫病专家咨询委员会委员闻礼永教授2003年至今担任“中心”的主任。“中心”现有技术人员26人，其中高级研究人员7人，中级11人，从事血吸虫病、土源性线虫病、丝虫病、肺吸虫病、弓形虫病及医学昆虫等方面的研究，全所共设四个研究室，即流行病室、药理室、诊断室和免疫生化室。
合作中心职责
（1）进一步研究阻断钩虫病传播的技术措施和控制蛔虫鞭虫感染的方案，最终为国家防治规划提出系统阐述和提供防治方法。
（2）对已批准的驱治肠道线虫药物用于群众性化疗的适用性作进一步研究。
（3）进一步开展钩虫病等土源性寄生虫病流行病学调查中应用的诊断手段的研究，改进评估防治工作的方法学。
（4）对血吸虫病预防药物和诊断技术作进一步研究。
（5）对食源性吸虫病及其他寄生虫病的流行病学诊断技术作进一步研究。
（6）与世界卫生组织协作举办培训班，编写有关肠道蠕虫病培训班的教材等。
合作中心联系方式
中心主任：闻礼永研究员
中心秘书：陆绍红副研究员
地 址：中国浙江杭州天目山路182号（邮编：310013）
浙江省医学科学院寄生虫病研究所
电 话：86-571-88215601 传 真：86-571-88215608
E-mail：ipdzjnet@mail.hz.zj.cn
合作中心1984-2006年工作
一、积极开展和完成“中心”职能范围的项目和WP/WHO资助的科研项目
（一）、承担的科研项目
“中心”自成立以来积极开展和完成“中心”职能范围的科研项目共206项，包括WP/WHO及其它国际合作课题、国家科技攻关项目、国家自然科学基金、卫生部课题、省自然科学基金等，其中有代表性科研项目如下：
1、 阻断钩虫等土源性线虫病最佳方案的研究 获卫生部/WHO二次项目资助，分三个阶段：①短期内控制流行的方案研究（1986-1988年）；②巩固监测方案的研究（1989-1992年）；③远期效果观察（1993-2000年），论文在国际SCI杂志发表。
2、 青蒿琥酯预防日本血吸虫病优化方案的研究 国家“九五”攻关，JRMC项目（1996-2000） 本研究率先为预防血吸虫病提供了一种高效、安全的口服药物，是血吸虫病预防药物研究的一项重大突破，并已应用于日本血吸虫病的预防。
3、 世界银行贷款浙江省血吸虫病控制项目（1992-2002） 项目在21个血防项目县（市、区）开展工作，完成了疾病控制、疾病监测、质量控制、健康教育、技术培训、应用科研、信息管理等工作，编写了《浙江省血吸虫病控制项目终期评估报告》。
4、 利用辐射技术控制食物源寄生虫感染性的研究 世界粮农组织/国际原子能利用机构（FAO/IAEA）的国际协作项目（1987-1992）。
5、 寄生虫螺类宿主分类与演化的研究 国家自然科学基金（1990-1993），美国费城自然科学院合作项目（1994-2002），论文在国际SCI杂志发表。
6、 血吸虫病预防药物及快速免疫断技术应用的研究 卫生部/WHO双年度项目（2002-2003）
7、 控制肠道寄生虫病新药物的推广应用 卫生部/WHO双年度项目（2004-2005）
（二）、发表的学术论文和获得的科技成果
“中心”1984-2006年共在国内外专业性期刊发表了有关土源性线虫、血吸虫、丝虫、弓形虫等寄生虫学或寄生虫病的学术论文535篇，其中国外期刊发表20篇；主编了《肠道寄生虫病防治手册》（1996），参加了《中国寄生虫文献提要》（人民卫生出版社，1990）、《The pomatiopsidae of Human China》（美国费城自然科学出版，1990）、《寄生虫病免疫学及免疫诊断》（江苏科技出版社，1991）、《中国弓形虫病》（亚洲医药出版社，2000）、《人体寄生虫学》（人民卫生出版社，2005）、《实用医学寄生虫学》（人民卫生出版社，2005）等12本专著的编写；获得国家发明专利1项，获新药证书1项，获国家级、省（部）厅级科技成果奖39项，这些项目的科研水平达到了国际先进、国内领先水平。其中5个有代表性的获奖成果如下：
1、 “中国阻断淋巴丝虫病传播的策略及技术措施的研究”（参加）获得2000年国家科技进步一等奖；
2、 “青蒿琥酯预防血吸虫病优化方案和推广应用的研究”获2003年国家科学技术进步二等奖；
3、 “伊维菌素治疗肠道寄生虫病的研究”获2003年度中华医学科技奖三等奖。
4、 “钴-60r射线控制弓形虫、华支睾吸虫等食物源性寄生感染性研究”获1992年中国预防医学科学院科技奖；
5、 “农业人口钩虫等土源性线虫病防治方案的研究” 获1998年浙江省科技进步三等奖。
二、人员培训
（一）、举办讲习班和研讨会
“中心”共举办了43期全国和全省性防治讲习班和研讨会，如“全国肠道蠕虫病流行病学及防治讲习班，1985年”、“全国食物源性人畜共患寄生虫病防治讲习班，1993年”、“全国血吸虫病免疫诊断技术讲习班，2003年”、“血吸虫病突发疫情处理高研班，2004年”等，共有1441人次的学员参加了培训。培训班编写了大量中、英文教材，邀请了国内外知名专家授课，并进行现场实践，提高了专业人员的业务水平。
（二）、人才培养
培养寄生虫学硕士研究生11名，联合培养博士生2名，继续培养在读硕士研究生3名，在读博士生3人。经WHO/TDR批准，选送多名科技人员赴澳大利亚昆士兰医学研究所、澳大利亚James Cook大学、美国哈佛大学、美国耶鲁大学、日本名古屋市立大学等进修寄生虫分子生物学，回国之后在科研工作中发挥着骨干作用，提高了“中心”的研究水平。
三、“中心”对外合作与交流
（一）、“中心”与WHO的合作
“中心”获得WP/WHO和卫生部1992/1993年、1994/1995年、2000/2001年、2002/2003年和2004/2005年的卫生技术合作项目的批准，共获28.2万美元资助，完成了“改进土壤传播蠕虫病控制”、“血吸虫病预防药物及快速免疫诊断技术应用的研究”、“控制肠道寄生虫病新药的研究”等项目的研究和培训内容，并选送科技人员出国深造。“中心”还获得WHO/TDR、WHO/WPRO的项目资助，开展了多项科研项目的研究，促进了学术水平的提高。“中心”主任多次参加了WHO与卫生部召开的“在中国的WHO合作中心主任会议”，并认真执行了会议的各项任务。
“中心”常得到WP/WHO、WHO/TDR以及WHO/寄生虫病规划局（PDP）等方面的学术资料或情报信息支持，加强了与国内外科学情报或学术交流。“中心”认真进行每年的工作总结，并向WHO递交年度报告。
（二）、其它对外合作与交流
“中心”积极开展国际合作项目的研究，与美国费城自然科学院、澳大利亚昆士兰医学研究所、日本名古屋市立大学等建立了合作关系，促进了科研水平的提高。“中心”积极邀请国外学者访问，共接待了来自美国、澳大利亚、日本、加拿大、朝鲜、丹麦、马来西亚、韩国等国家的81位专家、教授来“中心”参观访问，其中包括美国费城自然院软体动物部主任Dr.Davis、丹麦血吸虫研究所血吸虫学专家Dr.Kristensen、美国哈佛大学Dr.Donald Ham、美国耶鲁大学Peter John Hawdon、韩国国立汉城大学Dr. Jong-Yil Chai、日本名古屋市立大学医学部Dr.Nobuo Ohta等。同时“中心”多名成员曾赴波兰波兹南布、泰国玛希图大学热带病学院、墨西哥大学动学系等进行短期访问和学术交流。
四、学术会议交流
“中心”积极参加国际性寄生虫学会议，如“人畜共患寄生虫病研讨会”（泰国，1990）、“第14届国际热带医学和疟疾会议”（日本，1996）、“国际血吸虫病学术研讨会”（北京，1992；无锡，1998）、“第九届国际寄生虫学大会”（日本，1998）、“第17届寄生虫学国际联合大会”（丹麦，1999）、“第七届血吸虫病国际学术研究会”（巴西，1999）、“第三届国际食物源—水源性人畜人畜共患寄生虫病研讨会”（泰国，2000）、“第10届国际寄生虫学大会”（加拿大，2002）、“第七届环太平洋传染病大会”（上海，2002）、“亚洲血吸虫病网络会议”（老挝，2003）、“美日医学合作项目四十周年学术交流会”（日本，2004）、“国际血吸虫病学术会议”（菲律宾，2006）等，交流了学术论文25篇，提高了学术水平。
“中心”组织或主持了多次全国和全省的学术交流会，如主持“中国线虫学学术研讨会”（海南，1990；广西，1993）、、“青蒿琥酯预防日本血吸虫病推广应用研讨会（桂林2003）”“全国土源性线虫病防治方案研讨会”（ 杭州，2000）、“伊维菌素治疗肠道寄生虫推广应用研讨会（浙江2004）”“浙江省医学寄生虫学学术交流会（1989、1990、1996、1998、2000、2002、2006）”，在血吸虫、疟疾、土源性线虫、丝虫、肺吸虫、弓形虫等寄生虫病的免疫学、病原学、临床及防治对策等方面进行广泛的学术交流。
“中心”积极参加全国性学术会议，共有201人次参加了72次寄生虫学学术会议，交流了学术论文123篇，如“中华预防医学会第五次全国医学寄生虫学术会议”（2003）、“血吸虫病肝纤维化防治进展学术会议”（2003）、“寄生虫学国际学术研讨会暨中国动物学会寄生虫专业委员会第十次学术研讨会”（2005）、“全国血吸虫病防治研究青年学术交流会”（2006）等。
五、自我评价
在WP/WHO和卫生部的领导下，“中心”自成立以来成功地完成了各项工作并取得较好的成绩，有效地达到了建立中心的目的，在国内外有较大的影响，享有盛誉。
首先是科学研究，研究所从事土源性线虫病和血吸虫病的防治研究已有55年的历史，“中心”成立之后加强了科学研究，在钩虫等土源性线虫病方面，取得了有效的防治钩虫和蛲虫感染的防治方案以及监测、巩固防治效果的方法，为全国及浙江省提供了有关防治寄生虫病的技术方案；“中心”承担主编的《肠道寄生虫病防治手册》，为中国防治土源性线虫等肠道寄生虫病提供了完整、全面的技术资料，对防治工作的开展起到了关键作用；在血吸虫病研究方面中，首次在国内外研究发现青蒿琥酯能有效预防日本血吸虫病，该研究结果具有国际领先水平，为日本血吸虫病的防治作出了贡献，并获得国家科技进步二等奖；另外伊维菌素治疗土源性线虫病的研究成果等都具有开创性的成果。“中心”已具有承担国内外重大科研项目的能力和取得高质量科技成果的学术水平。
在培养技术人员方面，“中心”多次主办了全国、全省性培训班和学术研讨会，人员遍及全国各省，提高了防治人员的技术水平和工作能力，成为国内核心的专业培训中心。“中心”积极培养博士、硕士生，在WP/WHO及TDR的资助下，选派多人赴美国、丹麦、日本、澳大利亚进修分子生物学等专业技术，提高了人员素质和科研水平。
第三、学术交流和技术咨询方面，“中心”主持召开过全国范围的研讨会，享有较高声誉。在国际上，与美国、澳大利亚、丹麦、日本、巴西、泰国等国的学者开展过学术交流、课题合作或人员互访，建立了长期、友好的协作关系。“中心”成员积极参加国内外举办的专业学术会议，“中心”在沟通防治、科研信息等方面，发挥了积极作用。“中心”承担浙江省55个血防流行县的查治病、查灭螺技术指导、业务咨询等工作，为确保全省继续保持无本地新感染、急性感染病人（畜）和感染性钉螺，巩固血防成果方面发挥了重大的技术作用。
“中心”今后将进一步加强技术创新和对外交流，加强“中心”的自身建设，加强应用性研究开发和分子生物学建设，促进WHO中心工作的发展，为中国寄生虫病的防治作出贡献。
WHO Collaborating Centre for Research on Helminthiasis
General Conditions
Institute of Parasitic Diseases， Zhejiang Academy of Medical Science was designated as a WHO Collaborating Centre for Research on Helminthiasis （ “Centre” for short afterwards） by the MOPH and WHO Regional Office for the western Pacific（WPRO/WHO） in 1984. The main task of the “Centre” is to carry out the research and prevention works on helminthiasis， especially on soil-transmitted parasitic diseases and schistosomiasis.
Leaders of WHO， state and provincial government have been paying great attention and support to the “Centre”， especially Hiroshi Nakajima， the former Regional Director， WPRO/WHO and Chen Minzhang， the former Minisiter of MOPH visited “Centre” and gave directions on its working. Professor Mao Shou-bai and Zhao Wei-xian， famous parasitologist in China， once were consultants of the “Centre”. They had been giving effective directions and supports to the Centre’s work. Professor Song Chang-cun， the former head of the Institute， had been the director of the “Centre” during 1984 to 2002， Professor Wen Li-yong， the head of the Institute， is the director of the “Centre” from 2002. The Institute now has 26 research workers， among them there were 7 senior researchers， 11 medium level researchers， working on the studies of schistosomiasis， soil-transmitted intestinal nematode， filariasis， paragonimiasis， toxoplasmasis and Medical Entomology. The Institute has 4 departments， namely Epidemiology， Diagnosis， Pharmacology， Immunobiochemistry.
Terms of Reference of the Centre
（1） To carry out further studies on technical measures for interrupting transmission of hookworm disease and schemes on controlling roundworm and whipworm infection， and to formulate a systematic exposition for a nation control program and to furnish method as the ultimate goal；
（2） To conduct further studies on the applicability of approved vermifuges for treating intestinal nematodiasis in mass chemotherapy；
（3） To develop diagnostic tools for use in epidemiological survey of hookworm disease and other soil-transmitted parasitic diseases and to improve the methodology for evaluation of control work；
（4） To carry out further studies on drugs for schistosomiasis prevention and diagnostic techniques；
（5） To carry out further studies on epidemiology and diagnostic technique of food borne trematodiasis and other parasitic diseases；
（6） To collaborate with WHO in conducting training course and to compile teaching material for a training course concerning intestinal Helminthiasis.
Contact us
Director of the Centre： Professor Wen Li-yong
Secretary of the Centre： Associate Professor Lu Shao-hong
Address： Institute of Parasitic Diseases， Zhejiang Academy of Medical Sciences.
182 Tian Mu Shan Street， Hangzhou， Zhejiang （310013） The People’s Republic of China.
Tel： （86）571 88215601 FAX：（86）571 88215608
E-mail Address： ipdzjnet@mail.hz.zj.cn
WHO COLLABORATING CENTRE WORK REPORT（1984-2006）
I. Work performed in relation to the terms of reference or supported by WPRO/WHO
1. Research projects
Since the Centre’s designation， the “Centre” has developed and carried out 206 research projects cooperated with or supported by international organizations， National key Task Projects， international collaborating projects， National Natural Science Foundation， Provincial Natural Science foundation， 7 key projects among them are listed below：
（1） “Studies on optimum scheme to control the spread of soil-transmitted nematodiasis” This project was the item supported by WHO/MOPH twice， having three sub-subprojects： ①Studies on optimal measures to control the disease in a short time（1986-2000）； ②Studies on the strategy to consolidate and monitor the disease（1989-1992）. ③Long-term observation on the effect of soil-transmitted nematodiasis control（1999-2000） Research paper was published in international journal.
（2） “Studies on optimum scheme for prevention of schistosomiasis japonica with artesunate.” National Key Task Project in 9th “Five Year Plan /JRMC（1996-2000）. The study revealed that the artesunate is a safe， high-effective drug for prevention of schistosomiasis and carried out large-scale use of it.
（3） “Project of World Bank loan for schistosomiasis control in Zhejiang Province.” The project of World Bank loan for schistosomiasis control was carried out in 21 project counties. Main tasks （disease control， disease surveillance， quality control， health education， technical training， applied scientific research and information management） were implemented from 1992 to 2002. A“Final Evaluating Report on the Project of World Bank Loan for Schistosomiasis Control in Zhejiang Province”was compiled and was passed by the working conference of final evaluation report on project of World Bank loan for schistosomiasis control in Zhejiang Province and received favorable comment from the departments concerned of the higher authorities.
（4） “Studies on the use of Irradiation to control infectivity of Food-borne Parasites” FAO/IAEA （1987-1992）
（5） “Evolution and taxonomy of snail hosts of parasites” National Natural Science Foundation（1990-1993）， Collaborated with Philadelphia Academy of Natural Sciences U.S.A.（ 1988-2002）. Research papers were published in international journal.
（6） “Studies on prophylactic drug and practical use of rapid immunodiagnostic technique for schistosomiasis japonica” MOPH/WHO（2002-2003）
（7） “Expansion and application of new drug to control intestinal parasitic diseases” MOPH /WHO（2004-2005）
2. Papers published and awarded projects：
There have been totally 535 pieces of valuable papers published by the personnel of the “Centre” concerning schistosoma， food-borne nematodes， filarial， toxoplasma and other parasitic diseases. Personnel in the “Centre” supervised and took part in the editing of many monographs ，etc； The center edited the handbook of “Prevention and Control of Intestinal Parasitic Diseases”， and published in 1996. Professor Song Chang-cun is the chief editor. The “Centre’ took part in the editing of the 12 monographs， such as；
“The pomatiopsidae of Human China” （Philadelphia Natural Science Publishing House，U.S.A.1990）
“References Abstracts of Human Parasitic Diseases in China” （People’s Hygiene Publishing House， Beijing， 1990）
“Immune of Parasitic Infections and Immunodiagnostic Techniques” （Jiangsu Scientific and Technological Publishing House， 1991）
“Parasitology of human” （People’s Hygiene Publishing House， Beijing， 2005）
“Practical Medical Parasitology” （People’s Hygiene Publishing House， Beijing， 2005）
There was one state potent and one new drug certification approved. Total 39 projects were awarded Science and Technology Prize by national or provincial government. These scientific achievements of the projects reach the advanced level in China and international. The five key achievements listed as following：
（1） “Studies on tactics and technical measures to interrupt the spreading of lymphatic filariasis in China”（joint project） awarded First grade National Prize for creativity in science and technology in 2000.
（2） “The studies on prophylactic effect of artesunate on Schistosomiasis japonica” won a second award for national creativity in science and technology in 2003.
（3） “Studies on the effect of ivermectin against intestinal nematode infections” won a third grade national award for creativity in medical technology in 2003.
（4） “Studies on the use of Cobalt-60 irradiation to control infectivity of food-borne parasites―Toxoplasma gondii， Clonorchis sinensis and Paragonimus westernmost” won a national award for creativity in medical technology in 1992.
（5） “Studies on the scheme for the control on hookworm and other soil-transmmited intestinal nematode infections in farmer ” won a third grade provincial award for creativity in science and technology in 1998.
II. Education and Training
1. Conduct training workshop and syposium
Co-sponsored by the Ministry of Public Health of PRC and WHO， “Centre” conducted 43 national and provincial training workshops on prevention and control of parasitic diseases， including：
“Workshop on prevention and control of soil-transmitted helminthiasis， 1985”
“A national training course on prevention and control of intestinal parasitic diseases， 1991”
“A National Training Course on Control for Food-borne Parasitic Zoonoses， 1993”，
“A National Training Course on the New Rapid Diagnostic Techniques for Schistosomiasis 2003”
“Emergency measure and control of schistosomiasis japonica， 2004”
There were total 1441 participants from districts and cities （counties） over the country and province attended the workshop. The center compiled large number of teaching materials for the workshops. There were lectures， laboratory demonstrations， exchange of experience and discussion， watching videotapes along with field visit. The top specialist domestic and abroad had been invited to give the lectures to the classes. Through training， the professional capability of students was strengthened. They have played an important role in promoting the control work of these diseases.
2. Professional personnel Training
The “Centre” lays stress on training of professional personnel， going on to train and enroll postgraduates specialized in parasitology. There have been 11 persons gained master’s degree and 2 gained doctor’s degree. There are 3 working on their master degree and 3 on the doctor degree respectively at present. By the approval of WHO/TDR， some staff has been dispatched to the foreign country for advanced study in the field of molecular biology of parasites such as Queensland Institute of Medical Research， Australia； James Cook University， Australia； Harvard University， USA， Yale University， USA； Nagoya City University， Japan. They consist of mainstay of the scientific and technological contingents in the research work of the “Centre”， promoting the development of the “Centre”.
Ⅲ. Cooperation of the Centre
1. Cooperation with WHO
Approved by MOPH and WHO， the “Centre” got the funds for 1992-1993，1994-1995， 2000-2001， 2002-2003， 2004-2005 cooperative projects and obtained financial aid of 282，000 US dollars. The center has accomplished the task of cooperative projects such as； “Improved control of soil-transmitted helminthiasis”，“Studies on new rapid diagnositic techniques for schistosomiasis and application of artesunate as prophylaxis”， “Expansion and application of new drug to control intestinal parasitic diseases”. “Centre” also obtained the funds from WHO/TDR and WHO/WPRO for research projects， mainly on the prevention and control of principal parasites in China， promoting the research level of the academic standing. The head of “Centre” participated in all the Seminars for Directors of WHO Collaborating Centre in China held by WHO and MOPH， and implemented the task of assigned in the meeting.
“Centre” obtained the academic materials and information from WHO， WHO/TDR and WHO/PDP， strengthening the scientific information and academic exchange in China and international. “Centre” summarized the works annually and submitted annual report to WHO in time.
2. Other cooperation of the “Centre”
“Centre” has developed international collaborative works actively with Australia， U.S.A.， Korean and Japan， etc. 81 foreign experts on parasitology have been invited and paid the visit to the “Centre”， among them， Dr. G. M. Davis， director of the conchological department， Philadelphia Academy of Natural sciences， U.S.A； Dr. Kristensen， Danish Bilharziasis Laboratory； Dr. Donald Ham， Department of Tropical Health， Harvard School of Public Health， U.S.A.； Dr. Peter John Howdon of yale University U.S.A.； Dr. Jong-Yi Chai from the National Seoul University， Korean； Dr. Nobuo Ohta from Nagoya City University. Also， the Centre has dispatched scholars abroad for short time visiting and academic exchange. Destination includes： Poznan Poland； the Faculty of Tropical Medicine， Mahidol University in Bangkok， Thailand； the Faculty of Medical Veterinary and Zoology， Mexico University； the National Seoul University.etc.
Ⅳ. Academic exchange
“Centre” attended international symposium actively， presented 25 research papers. Some international meetings listed as below： “the 33rd SEAMEO-TROPMED Regional Seminar” （Thailand，1990）； “International Symposium on Schistosomiasis” （Beijing，1992； Wuxi，1998）； “Fourteenth International symposium on Tropical Medicine and Malaria” （Japan，1996）； “Ninth international symposium on parasitology”（Japan， 1998）； “17th International conferece of the World Association for the Advancement of Veterinary Parasitology”（Denmark，1999）； “7th International Symposium on Schistosomiasis”（Brazil，1999）； “The 3rd international symposium on food-borne water-borne amphixenosis” （Thailand， 2000）； “the 10th international conference of parasistolgy ”（Canada，2002）； “the 7th round-the-Pacific Ocean conference on infectious diseases” （Shanghai，2002）； “Reagional network of Asian schistosomiasis” （Laos， 2003）； “U.S.-Japan conference of medical academic exchange”（Japan，2004）； “the international conference of Schistosomiasis”（Philippines， 2006）.
“Centre” conducted or hosted several national and provincial symposium， such as “National Symposium of Medical Nematode of Chinese Medical Parasitology Association（Hainan，1990）； “National symposium of spreading application scheme for prevention of schistosomiasis japonica with artesunate （Guilin， 2003）” “National workshop on control scheme of soil-transmitted nematodiasis” （Hangzhou， 2000）； “National symposium of spreading application scheme for ivermectin against intestinal nematode infections （Hangzhou， 2004）”“Zhejiang Scientific Exchange Meeting of Parasitology （1989，1990，1996，1998，2000，2002，2006） ”. At the meetings， representatives exchanged their experiences and discussed the control and research work on hookworm， falaria and trichuris， schistosomiasis， malaria， soil-transmitted helminthiasis， toxoplasmosis， paragonimiasis， and information on immunology， pathogen， clinical， strategy of control.
Members of the center attended the important conferences in china on the parasitic diseases， such as： “The fifth annual academic meeting on medical parasitic diseases” （2003）； “Academic meeting on control of liver fibrosis caused by schistosomiasis” （2003）； “the 10th seminar of Chinese Zoological Society Board of parasitic diseases” （2005）； 201 staff/time participated some 72 national academic meetings， 123 scientific papers have been present.
Ⅴ. Self-evaluation
Since its designation as a WHO Collaborating Centre， the Institute of Parasitic Diseases，Zhejiang Academy of Medical Sciences has energetically implemented the activities included in its terms of reference and has made remarkable achievements in all aspects of scientific research， disease control， training professional personnel， domestic and international academic exchanges.
In research studies， works on prevention and control of soil-transmitted helminthiasis and schistosomiasis have been carried out over 55 years by the institute， the research work has been enhanced after the “Centre” established. The work on prevention and control of hookworm and other soil-transmitted helminsiasis has gained remarkable achievement. The effective control and consolidation schemes and surveillance methods on hookworm and enterobius infections have been developed and applied nationwide. The center edited key handbook on prevention and control of intestinal parasitic diseases， which provided efficient technical schemes for diseases control around China； In the aspect of preventing schistosomiasis， the studies revealed that artesunate could be in prophylaxis of schistosomiasis effectively. This is the first report around the world on the topic and this achievement was awarded as Second National Prize for Creativity in Science and Technology in 2003. In regard to ivermectin study， it was affirmed for the first time that ivermectin has satisfactory effect on driving out intestinal nematode， especially for roundworm and whipworm， it is a project of high technologic level and won a prize. In short， the “Centre” has been capable to carryout and accomplish significant research projects， and to gain high quality scientific and technological achievements.
In aspect of training and bringing up qualified personnel， in order to raise the techniques and work ability of grassroots personnel who were engaged in parasitic disease control work， the “Centre” has conducted training courses for more than 40 times， more than 1400 participants from countrywide attended these classes. Also the “Center” sends experts regularly to endemic areas to direct technical work. The “Center” has become one of the key training and research centers in China. The “Centre” devoted much attention to the training of quantified personnel， 2 Doctors and 11 Masters were brought up. Several members of the “Centre” have been dispatched to foreign country for advanced study on molecular biology and other professional technique. Therefore， technologic level of the “Centre” has been raised constantly.
With regard to technical consultation and academic exchange， the “Center” has convened and presided over several countrywide seminars， thus enjoy good reputation. Some members of the “Centre” took part in the MOPH Parasitic Diseases Advisory Committee， especially in regard to control work of Soil-transmitted nematodiasis and schistosomiasis. International academic exchange or joint project was relatively concentrated， mainly with scholars from U.S.A.， Australia， Denmark， and Japan friendly and complemental relationship of cooperation has been established. Personnel of the “Centre” attended international professional meetings in USA， Japan， Brazil， Denmark， Thailand and in China actively. The “Centre” has played a key role in academic exchange. For the schistosomiasis control technical consultation work， the "center" has been carrying out works in aspects of monitoring of epidemic situation and professional training and consult for 55 counties in Zhejiang province； So far， no local new infections， acute infection patients （animal） and positive oncomelania snail occurred. The great achievement has been gained on schistosomiasis control in Zhejiang province.
The Centre has played an important role in improving the quality of research workers and exchanging research information. In the future， the “Centre” will do its best as usual on its task， especially in the further technological innovation， also the center will enhance the cooperation with WHO and the collaborators around the world， making the significant contribution to control of parasitic diseases in China.
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